There was a game by EA called The Majestic that didn't last long. Played in college. It was a "puzzle" game that would interact with you in real life. You would get AIM's, phone calls, e-mails, etc. Crazy shit but really fun.
First phone call from that game happened around 3AM one morning and I was told to stop pursuing what I was doing. Couldn't tell they were recorded calls the first couple of calls.
Beating Zelda Ocarina of Time was pretty damn memorable. Lotsa moments, can't recall them all
http://en.wikipedia.org/wiki/Majestic_(video_game)