Start to Finish
 

I havent started a game and played it through without starting another game in as long as I can remember. I would really enjoy playing through a game, but I cannot decide which one.

Perhaps you lot can help me and I ask, please no spoilers.

Mass Effect 1
Mass Effect 2
Fallout 3
Dead Rising
Crackdown (finished over a long time)
Fable 2
Resident Evil 5
Saints Row 2
GTA 4
Red Dead Redemption (finished over a very long time and many interruptions)
Gears of War
Modern Warfare 2 (Finished already and not a fan or replays on shooters)
Black Ops (Havent started Single Player yet)
Lego Indy Jones and Lego Batman

I too have dead rising to play. Never got past the first night where the zombies eyes turn red, the fact that if you leave it too long always had me starting over.
So IMO that's a good game to play solely.
From that list I have these waiting for me to play:
Fallout 3 - had it on my flashed 360. Got banned so never finished, just bought for £4
Resident Evil 5 - completed ages ago, bought again, £10 for resi 5 and a controlller :)
Saints Row 2 - Never finished, was in love with the first
GTA4 - Want to complete again sometime.
Lego Batman - Got off Goozex, barely touched

I am thinking GTA 4 as its a more a pickup and play sort of game.

Mass Effect.

By that I mean both, ready for 3

Yeah, thats the problem. If I play the first, I will undoubtedly play the second and the buy the third.

I know they are good games and all, but I would want a break from them in the next 6 months haha.

Thinking im going to go with Mass Effect and GTA4.

Mass Effect. You will play them again before the third comes out. Everyone plays that game, then plays again to refine their story

I've recently started Mass Effect, but have been distracted by Uncharted 2, The Secret Of Monkey Island, and Duke Nukem 3D.