[Jeritron]

I don't. I'd be willing to bet money on a new Spidey, a new MJ, and a new director.
It's remarkable that they made it to 3 films as consistent and strong as they did, and managed to keep the same cast and director. That's a feat no other comic movie series has managed to do thus far. That's of course thanks to 3 movie deals and contract options signed on to. This can and will be duplicated in other projects, but no actor or director is inking a deal any longer than that early on. If they can work out a way to keep the same components on board for another movie or more, I'll be even more happy.
But I don't hold out much hope for Macguire and Raimi sticking around for a fourth and beyond.
Just like I don't hold much hope for Bale and Nolan sticking around for more than 3 over on the DC side of things.

Let's be realistic, it's the type of thing I learned long ago about movies. Great actors and directors don't want to devote more than a decade to the same project, regardless of how good it is. Especially when they're as successful at it as they are and it opens doors for new things.
I don't doubt Raimi, Nolan or anyone elses love for the source material, but they're actors not comic die hards.