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Noid, you do make some points, but I have to side with Fox here. I think you are right in that JD isn't as fun as he used to be, but he is the main character and he does dictate the mood of the whole show. I don't think it's that Zach Braff has run its part, I think it's just that the show might have. When you watch the new episodes, it's just too obvious that JD and Turk are older guys now, and it just doesn't work.
Getting rid of Carla would ruin the show even more. Beyond the obvious storylines (does she just leave Turk randomly?), her attitude is such an important element in the show. There has always been something comforting in Carla and Doctor Cox. I think some of the best episodes in the series were when Cox lost his edge and almost quit, because suddenly there was nothing to fall back on anymore.
I really think the only main character that the show could replace is Elliot, but even that would be hard. Scrubs is a great show, but shows only have so long of a shelf life, and I hope they don't tarnish this by going too long.
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