"and if you're not down with that, we got two words for ya!..."
Audience: "SUCK IT!"
followed by
(cue up but don't play sound, just play it to 0:23 muted, and then when you need it right after the punch line, hit the music full tilt.)
also from DX:
"Are you ready?
NO, I SAID ARE YOU READY?!
Then, for the young lady in my life, and the millions watching on the World Wide Web (if you really wanna piss your gf off that is by doing such a cruel prank like that...the "and millions" part, obv.), Lllllllllllllllllllllllllllllet's get ready to 'SUCK IT!' "
Kinda mediocre suggestions. I suggest use only after careful deliberation and with only perfectly timed discretion.