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The whole 'infected'/sickness thing, there are different versions or instances of what is supposedly out there....
The first time the idea of infection come up was with the French woman in season 1, she claimed it had infected her team and she was forced to kill them. In season 5 we saw the smoke monster take one or some of her team into the ruins and underground, and kill others. Robert I think was his name, he came back to the beach and appeared to be friendly to the French woman (this is when Jin was time shifted back to when they arrived and she was still pregnant), but he wanted to kill her. So wherever he went, he was either 'infected' or possessed by the MIB whether he had died or not, like Sayid or Claire. So since he wanted her dead, he was infected, acting in the interest of the MIB, for what reason I don't know....maybe to actually kill Alex, her unborn child? An attempt that might of been re-attempted when Widmore claimed it was the will of the Island for the child to be killed. I believe what we are being told about him wanting everyone dead is true.
Then in Season 2 with Desmond. Kelvin claimed there was an infection out there, so he wore the suit. But then he and we saw that it was bollocks because the suite had a tear and he was really venturing out to fix Desmond's boat. But Desmond still injected himself everyday up until he killed Kelvin I think. The same injection Ethan gave Claire and her baby. Not forgetting the 'QUARANTINE' notices on the Swan hatch door, and even the Arrow station with the tailies.
But what's going on now, to do with Claire and Sayid - I don't know exactly how it works, but with Sayid - 'he was dead for 2 hours' according to Hurley, and then was back - think it's something about them dying, and the MIB able to control them. And I always thought....that when Keamy's men shot a rocket at Claire's house in Dharmaville in season 4 and she was hurt, and Sawyer saved her, although it was moments after it happened and Sawyer found her, what if that explosion actually killed her? she vanished into the jungle and found her 'father', who was really the MIB very easily. Maybe the MIB 'took her' and started to poison her soul straight away when she died then and there. It's just an idea.
If she did not die, it must simply be that with enough manipulation and power, the MIB can begin to 'claim' people's soul. And if they are weak enough, or tempted by what they perceive to be good (Claire, her father and the promise of Aaron. Sayid, the promise of Nadia) then they are 'amenable for coercion' (a term that undercover cop used to describe Locke, who would eventually become the ultimate pawn).
So yeah, with regard to what kind of infection it is - it's like supernatural psychological I guess. It's about being able to exploit people's emotional/spiritual characteristics and manipulate the physical (dead body theory). How he is infecting them? - still don't actually know what he is, in the simplest idea, I guess he and Jacob are two entities on a completely different and higher plane of existence to mere mortals. It will be interesting to finally find out what they are, how they became 'trapped' in this whole service to the Island thing. Not forgetting the Island itself. The MIB saw that kid who told him about breaking the rules, so MIB is not the know all and end all to this whole mystery, which is pretty fuckin sweet.
Least that's my take on it at the moment. Even with a theme with the sickness/infection, there's a lot to think about and wonder what the deal is.
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