No, because I have played it probably 5 times or more. Replayability is there to no end. Using different party members, getting different results. Before my friend's modded box bit the dust, we had a paragon playthrough, renegade, and neutral saved on it for ME1 and ME2. One where we saved everyone, and one where almost everyone died.
Hell, I just love hearing the different dialogue if you have different party members at certain points in the game.
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