Always liked when Vader would bust out the Vader sault from the top rope every once in a while. Looked great as a visual because he was athletic to hit it.
Same with Undertaker diving over the top rope. Kane countering that and throwing him through the announce table at their first Mania encounter was a great spot in a big man match.
Like stated already, as long as it feels natural within the context of the match and the big guy is agile enough I think it definitely has a place.
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