If I had to use Big Show in WWE today, teaming him with a great babyface-in-peril would be a good way to go. I'm not a big fan of sticking veterans together because you have nothing else for them, but how about Big Show & Goldust as a team? Goldie still takes a fucking beating like a champ and drums up sympathy. Show can tag in and just go wild. They've also got that "cinematic" connection in that Show was originally somewhat thematically presented as a sort of "movie monster" come to life. And they've both had finishers called "The Final Cut."
R-Truth could be a heel, team with Miz again, and Miz has that "Hollywood" persona as well. Could make an interesting mid-card tag feud on RAW...
Ah, who am I kidding? It would suck.