A lot of the random encounters are meant to work like that. You pass a certain area of the map and you might see one person in need of help or you may even come across a cop or cops dealing with a criminal or group of criminals. I know for sure those re-spawn in the same area every time, just not sure what the reset interval is. Obvious case in point: up in Paleto Bay the armored car usually only shows up once a week before resetting each time.
It should go without saying but it also may seem to happen if you do the Strangers and Freaks stuff. Took my dumb ass like 15 seconds to go from playing as Trevor who I'd been using to collect all the spaceship parts to remembering, oh, yeah, I've gotta switch to Franklin and wait for the guy to call Franklin.
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