Sen's Fortress is annoying as fuck. Real chore to get through. Don't go there with many souls or humanity stored up. Fight the big snake guys by circling round behind them and back-stabbing, as they are pretty slow.
Once you get through there and to Anor Londo, as Requiem says you can start making some glorious weapons. Quelaag's Chaos Sword became my main weapon on my last playthrough, it scales with humanity and minces all normal enemies in 1-2 hits with 10+ humanity. It's made with Quelaag's soul and a +10 curved sword. There's a couple of spots for farming humanity later in the game.
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